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J Bacteriol. 1969 October; 100(1): 11-13
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Mode of Action of Albocycline, an Inhibitor of Nicotinate Biosynthesis

Fritz Reusser

1 The Upjohn Company, Kalamazoo, Michigan 49001

ABSTRACT

The antibiotic albocycline blocks the synthesis of nicotinate or nicotinamide in Bacillus subtilis cells. The inhibitory activity of the agent is fully reversed by nicotinic acid, nicotinamide, and, to a moderate extent, also by quinolinate. This suggests that in B. subtilis the antibiotic interferes with a reaction step occurring prior to the formation of quinolinate within the biosynthetic pathway leading to nicotinate.

J Bacteriol. 1969 October; 100(1): 11-13
Copyright © 1969 American Society for Microbiology. All Rights Reserved.





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Appl. Environ. Microbiol. Infect. Immun. Eukaryot. Cell
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Copyright © 1969 by the American Society for Microbiology. All rights reserved.