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J Bacteriol. 1969 November; 100(2): 1144-1146
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Aminoglycoside Antibiotics: Inactivation by Phosphorylation in Escherichia coli Carrying R Factors

B. Ozanne, R. Benveniste, D. Tipper and J. Davies

Department of Biochemistry and Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706

ABSTRACT

R-factor strains which are streptomycin-resistant and spectinomycin-sensitive have been found to inactivate streptomycin by a new mechanism. The 3'-OH group of the 2-deoxy-2-methylamino-L-glucopyranosyl moiety is phosphorylated.

J Bacteriol. 1969 November; 100(2): 1144-1146
Copyright © 1969 American Society for Microbiology. All Rights Reserved.



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