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J Bacteriol. 1969 November; 100(2): 956-961
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Inhibitor-Induced Shift-Downs in Escherichia coli

Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

ABSTRACT

A shift-down response in Escherichia coli cells has been brought about by moderate concentrations of azide or cyanide. Early events of the response included a preferential inhibition of ribonucleic acid relative to deoxyribonucleic acid synthesis, a degradation of polyribosomes, and an inhibition of protein synthesis followed by a transient relief. These changes were entirely comparable to those observed with nutrient-induced shift-downs. The influences of various nutrient supplements on an azide shift-down were examined, and methionine was found to relieve effectively the inhibition of ribonucleic acid synthesis in some strains of cells.