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J Bacteriol. 1969 November; 100(2): 969-973
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Inhibitory Effect of Penicillin on Proline Synthesis in Escherichia coli

Annette Baich

1 Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331

ABSTRACT

The production of glutamic {gamma}-semialdehyde, an intermediate in the synthesis of proline, was inhibited in Escherichia coli by physiological concentrations of penicillin. Sucrose (0.6 M) and sodium chloride (0.1 M) prevented penicillin inhibition of glutamic {gamma}-semialdehyde synthesis. Cells which were in the stationary phase, or which had been permitted to metabolize without growth, were insensitive to the effects of penicillin on glutamic {gamma}-semialdehyde synthesis.


J Bacteriol. 1969 November; 100(2): 969-973
Copyright © 1969 American Society for Microbiology. All Rights Reserved.







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