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Induction of Kynureninase in Neurospora

^a Biology Department, Battelle Memorial Institute, Pacific Northwest Laboratories, Richland, Washington 99352

ABSTRACT

Induction of kynureninase in a homogeneous population of mycelia in balanced growth was studied. Induced synthesis of enzyme was apparent 10 min after addition of inducers (tryptophan, kynurenine, and N-formylkynurenine). Experiments with cycloheximide-inhibited cells indicated that initiation of message transcription occurred about 4 min after addition of inducers. Lifetime of the message in the absence of inducer was of the order of 5 min. Experiments with mutants showed that N-formylkynurenine was the probable inducer of physiological importance.

¹ Present address: Department of Biology, Southern Oregon College, Ashland, Ore. 97520.

² Present address: Battelle Seattle Research Center, Battelle Memorial Institute, Seattle, Wash. 98105.