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J Bacteriol. 1970 August; 103(2): 375-381
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Developmental Regulation of {alpha}-Mannosidase in Dictyostelium discoideum

William F. Loomis Jr.

Department of Biology, University of California, San Diego, La Jolla, California 92037

ABSTRACT

The specific activity of {alpha}-mannosidase (EC 3.2.1.24) has been found to increase more than a thousandfold during development of the cellular slime mold, Dictyostelium discoideum. The enzyme accumulates in both spore and stalk cells. Studies with preferential inhibitors of macromolecular synthesis indicate that accumulation of {alpha}-mannosidase requires concomitant protein synthesis and prior ribonucleic acid synthesis. Control of the period of synthesis by the overall developmental program is demonstrated in two temporally deranged morphological mutants. {alpha}-Mannosidase is found in lysosomes of D. discoideum in association with other acid hydrolases which may be involved in metabolism of extracellular polysaccharide.

J Bacteriol. 1970 August; 103(2): 375-381
Copyright © 1970 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Srinivasan, S., Alexander, H., Alexander, S. (1999). The Prespore Vesicles of Dictyostelium discoideum. PURIFICATION, CHARACTERIZATION, AND DEVELOPMENTAL REGULATION. J. Biol. Chem. 274: 35823-35831 [Abstract] [Full Text]  
  • Coukell, M. B., Cameron, A. M., Adames, N. R. (1992). Involvement of intracellular calcium in protein secretion in Dictyostelium discoideum. J. Cell Sci. 103: 371-380 [Abstract]  


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