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Interaction of Concanavalin A with an Arabinogalactan from the Cell Wall of Mycobacterium bovis

Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48104
The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan

ABSTRACT

The arabinogalactan isolated from the cell wall of Mycobacterium bovis reacts to form a precipitate with concanavalin A, the phytohemagglutinin of the jack bean. A typical precipitin-like curve is obtained when increasing amounts of the polysaccharide are added to a constant quantity of concanavalin A. Inhibitor studies suggest that concanavalin A reacts with the arabinogalactan by interacting with the C-2, C-3, and C-5 hydroxyl groups of the -D-arabinofuranosyl residues situated at the chain ends of this polysaccharide.

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