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J Bacteriol. 1971 February; 105(2): 477-482
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Mutation Affecting Activity of Several Distinct Amino Acid Transport Systems in Saccharomyces cerevisiae

^a Laboratoire de Microbiologie, Facultè des Sciences, Universitè de Bruxelles, and Institut de Recherches du C.E.R.I.A., B-1070 Brussels, Belgium^,2

ABSTRACT

Mutations at the apf locus selectively depress the activity of a number of distinct amino acid permeases in Saccharomyces cerevisiae. The activity of the general amino acid permease and specific amino acid permeases is decreased, but the uptake of pyrimidines and adenine is unaffected. Mutations at the apf locus are allelic to the aap mutation isolated by Surdin et al. Amino acid uptake is normal in a heterozygous diploid (apf/+) and in a tetraploid strain with only one functional allele at the apf locus.

¹ C. H. holds a predoctoral fellowship from the I.R.S.I.A.

² Address for request of reprints: Institut de Recherches, C.E.R.I.A. Av. E. Gryzon, 1, B-1070 Bruxelles, Belgium.