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Inhibition of Growth of Salmonella typhimurium and of Threonine Deaminase and Transaminase B by ß-Chloroalanine

¹ Department of Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213

ABSTRACT

ß-Chloro-L-alanine (CA) was found to inhibit the growth of Salmonella typhimurium. The inhibition was overcome by isoleucine plus valine. CA inhibited the activity of threonine deaminase and transaminase B in vitro. The inhibition of threonine deaminase was reversible and was not affected by desensitization to isoleucine inhibition. Transaminase B was irreversibly inactivated. Derepression of some of the isoleucine and valine biosynthetic enzymes was achieved by growth of wild-type cells on low levels of CA.

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