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Genetic Analysis of Lysine Auxotrophs of Staphylococcus aureus¹

Department of Microbiology, The Pennsylvania State University, The Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033
Department of Microbiology, Hahnemann Medical College, Philadelphia, Pennsylvania 19102

ABSTRACT

The genetics of lysine biosynthesis in Staphylococcus aureus was examined by a transductional analysis of lysine auxotrophs. These mutants had previously been grouped according to their biochemical characteristics. The mutant sites appeared to be closely linked. Complementation was observed between different groups but not between mutant strains belonging to the same group. A strain was detected which seemed to have a mutant control region. Evidence is presented to support the hypothesis that the lysine biosynthetic region functions as an operon.

¹ This work was presented in part at the 69th Annual Meeting of the American Society for Microbiology, Miami Beach, Fla., May 1969.