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J Bacteriol. 1971 February; 105(2): 556-564
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Effects of N-Hydroxyurethan on Viability and Metabolism of Escherichia coli

^a Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

ABSTRACT

Exposure of growing cells to low levels of N-hydroxyurethan (approximately 0.05 M) resulted in loss of colony-forming ability. This was accompanied by degradation of cellular deoxyribonucleic acid. When the concentration of N-hydroxyurethan was increased to 0.2 M, bacteriostasis was the primary manifestation. The lethal action of the drug was prevented by contreatment with chloramphenicol or azauracil or by uracil-deprivation of a bacterial strain requiring this pyrimidine for growth.

¹ Present address: The Biological Laboratories, Harvard University, Cambridge, Mass. 02138.