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J Bacteriol. 1971 February; 105(2): 565-572
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Recovery from N-Hydroxyurethan-Induced Death

^a Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

ABSTRACT

Bacteria (Escherichia coli) can recover from the lethal action of N-hydroxyurethan when they are incubated in drug-free liquid medium. This recovery, which is dependent upon energy metabolism, does not occur on solid medium. Recovery is accompanied by repair of the cellular deoxyribonucleic acid (DNA). A bacterial mutant deficient in DNA polymerase was extremely sensitive to the lethal action of hydroxyurethan. Data are presented which support the concept that DNA replication and DNA repair are mediated by different enzymes and that only the former process is inhibited by hydroxyurea.

¹ Present address: Biological Laboratories, Harvard University, Cambridge, Mass. 02138.