This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rothman-Denes, L. Articles by Martin, R. G. Search for Related Content PubMed PubMed Citation Articles by Rothman-Denes, L. Articles by Martin, R. G.

Two Mutations in the First Gene of the Histidine Operon of Salmonella typhimurium Affecting Control

^a Laboratory of Molecular Biology, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

ABSTRACT

Two strains with mutations in the first structural gene of the histidine operon of Salmonella typhimurium were characterized. (The first structural gene specifies the first enzyme of histidine biosynthesis, phosphoribosyltransferase, which is sensitive to feedback inhibition by histidine.) One mutation, hisG3934, results in a phosphoribosyltransferase which is no longer sensitive to feedback inhibition by histidine but is instead subject to inhibition by aspartic acid. The other mutation, hisG3935, allows the histidine operon to be partially repressed by several amino acids, including aspartic acid. Analysis of hisG3935 is consistent with the hypothesis that phosphoribosyltransferase is directly involved in the regulation of the histidine operon.

¹ Present address: Department of Biophysics, The University of Chicago, Chicago, Ill. 60637.

This article has been cited by other articles:

• Goldberger, R. F. (1974). Autogenous Regulation of Gene Expression: The mechanism by which a protein directly controls expression of its own structural gene is described. Science 183: 810-816 [Abstract]