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Mutation of Saccharomyces cerevisiae Preventing Uptake of S-Adenosylmethionine

¹ Department of Bacteriology and Public Health, Washington State University, Pullman, Washington 99163

ABSTRACT

A mutant has been isolated whose aberration severely restricts the ability of cells of Saccharomyces cerevisiae to take up S-adenosylmethionine. The mutation apparently also affects adenosylhomocysteine uptake, but not that of the S-adenosylmethionine moieties adenine, homocysteine, homoserine, or methionine, nor the sulfonium compound, S-methylmethionine. It is a single, chromosomal mutation whose expression is not dependent on the presence of ammonium ions.

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