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Induction of Colicin la at High Temperature

^a Research Institute of Epidemiology and Microbiology, Sofia, Bulgaria

ABSTRACT

Induction of colicin la at a high temperature (42 C) was demonstrated in a wild strain of Shigella sonnei. After transfer of the Col factor, a similar effect was observed in those recipient cells acquiring colicinogeny. The induction is suggested to be due to the presence of a thermosensitive colicin repressor. The wild-type strain segregated sensitive cells and showed heterogeneity in colicin production.

¹ Present address: Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, Pa. 19104.