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J Bacteriol. 1971 August; 107(2): 397-400
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Growth Rate of Escherichia coli at Elevated Temperatures: Reversible Inhibition of Homoserine Trans-Succinylase

Eliora Z. Ron1 and M. Shani2

Department of Microbiology, Tel Aviv University, Tel Aviv, Israel
2 Bacterial Physiology Unit, Harvard Medical School, Boston, Massachusetts 02115

ABSTRACT

The preceding paper (10) showed that the growth of Escherichia coli is slowed, without killing, at 40 to 45 C, and that in the several strains tested the cause is a decrease in the activity of homoserine trans-succinylase. These temperatures are now shown to inhibit the enzyme directly, in crude extracts and after partial purification. The effect is rapid and is immediately reversible, unlike the progressive and slowly reversible changes of conventional denaturation.


J Bacteriol. 1971 August; 107(2): 397-400
Copyright © 1971 American Society for Microbiology. All Rights Reserved.




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