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J Bacteriol. 1971 August; 107(2): 486-490
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Mutants of Escherichia coli Sensitive to Antibiotics

Herbert L. Ennis

1 Roche Institute of Molecular Biology, Nutley, New Jersey 07110

ABSTRACT

Mutants of Escherichia coli sensitive to the antibiotic synergistin A, an inhibitor of protein synthesis, were isolated. These mutants were pleiotropic, being also sensitive to a large number of unrelated antibiotics and to lysis by detergents. These pleiotropic responses indicated that the mutations affected cell wall or membrane synthesis. Consequently, selection for antibiotic-sensitive mutants constitutes a useful means for isolating cell wall or membrane mutants.

J Bacteriol. 1971 August; 107(2): 486-490
Copyright © 1971 American Society for Microbiology. All Rights Reserved.





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Appl. Environ. Microbiol. Infect. Immun. Eukaryot. Cell
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Copyright © 1971 by the American Society for Microbiology. All rights reserved.