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Effect of Pleiotropic Carbohydrate Mutations (ctr) on Tryptophan Catabolism¹

^a Webb-Waring Institute for Medical Research and the Department of Biophysics and Genetics, University of Colorado Medical Center, Denver, Colorado 80220

ABSTRACT

The pleiotropic ctr mutation has been shown to affect tryptophan uptake and tryptophanase formation. Genetic reversions are of two types: (i) complete, restoring to wild type, located at 46 to 47 min; (ii) partial, restoring only tryptophanase synthesis, located at 73 min. In some strains the effect of ctr mutations could be reversed by cyclic adenosine 3',5'-monophosphate (cAMP) plus tryptophan. A mutant producing tryptophanase constitutively was suppressed by a ctr mutation. Production of tryptophanase in this suppressed strain was not restored by the addition of cAMP, but required cAMP plus tryptophan.

² Present address: Department of Biology, Massachusetts Institute of Technology, Cambridge, Mass. 02139.

¹ Contribution no. 461, Department of Biophysics and Genetics, University of Colorado Medical Center, Denver, Colo. 80220.