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Phosphorolysis of 5-Fluoro-2'-Deoxyuridine in Escherichia coli and Its Inhibition by Nucleosides

^a Department of Genetics, University of Leicester, England
Department of Biochemistry, Tel-Aviv University, Tel-Aviv, Israel

ABSTRACT

The effect of ribonucleosides and deoxyribonucleosides on the phosphorolysis of 5-fluoro-2'-deoxyuridine (FUdR) was examined in cells of Escherichia coli. All nucleosides tested except guanosine and deoxyguanosine inhibited phosphorolysis. By using genetically marked strains it was found that in vivo FUdR is a specific substrate of thymidine phosphorylase.

¹ Present address: Department of Biochemistry, Tel-Aviv University, Tel-Aviv, Israel.

² Present address: Department of Plant Genetics, the Weizman Institute, Rehovot, Israel.