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Regulation of the Methionine Feedback-Sensitive Enzyme in Mutants of Salmonella typhimurium

¹ Laboratoire d'Enzymologie, C.N.R.S., 91 - Gif-sur-Yvette, France

ABSTRACT

Assay of the first enzyme unique to methionine biosynthesis, homoserine-O-transsuccinylase, in metJ and metK regulatory mutants of Salmonella typhimurium showed that synthesis of the enzyme was derepressed seven- and fourfold, respectively. The possibility of noncoordinate regulation of the methionine enzymes is discussed. In metA feedback-resistant mutants, the enzyme activity can be inhibited in vitro by 10 mMS-adenosylmethionine but not by 10 mM L-methionine; hence, the synergistic inhibition found for the wild-type enzyme is not effective in these latter mutants.

This article has been cited by other articles:

• Usuda, Y., Kurahashi, O. (2005). Effects of Deregulation of Methionine Biosynthesis on Methionine Excretion in Escherichia coli. Appl. Environ. Microbiol. 71: 3228-3234 [Abstract] [Full Text]