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Isolation of Temperature-Sensitive Mutants of Schizosaccharomyces pombe¹

^a Laboratorio di Mutagenesi e Differenziamento del C.N.R. and Istituto di Genetica dell'Università, Pisa, Italy

ABSTRACT

Seventy-one mutants of the yeast Schizosaccharomyces pombe that were able to grow on complete medium at 25 C but not at 37 C were isolated. Strains selected for further study showed: (i) single gene mutation and (ii) cell lengthening at the restrictive temperature. Preliminary characterization of 13 mutants is reported. Seven of them have a less pronounced synthesis of deoxyribonucleic acid at the restrictive temperature, and four of them seem to be affected in cell division.

¹ Publication 28 from the Laboratorio di Mutagenesi e Differenziamento del C.N.R., Pisa, Italy.