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J Bacteriol. 1972 March; 109(3): 1014-1019
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Effect of D-Cycloserine on Transformation in Group H Streptococcus, Strain Challis

Dennis Perry

1 Department of Microbiology, Northwestern University Medical School, Chicago, Illinois 60611

ABSTRACT

D-Cycloserine (D-CS), a selective inhibitor of bacterial cell wall biosynthesis, inhibited transformation in group H streptococcus, strain Challis, by preventing the development of the competent state. The incubation of strain Challis cells with D-CS resulted in the production of a substance which inhibited the action of competence factor on these cells. D-CS had an enhancing effect on transformation when deoxyribonucleic acid uptake or phenotypic expression was allowed to occur in its presence.

J Bacteriol. 1972 March; 109(3): 1014-1019
Copyright © 1972 American Society for Microbiology. All Rights Reserved.





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Appl. Environ. Microbiol. Infect. Immun. Eukaryot. Cell
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