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J Bacteriol. 1972 March; 109(3): 1170-1174
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Effect of Phenethyl Alcohol on Deoxyribonucleic Acid-Membrane Association in Escherichia coli

¹ Department of Radiation Biology and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642

ABSTRACT

The effect of phenethyl alcohol (PEA) on deoxyribonucleic acid (DNA)-membrane attachment was examined by means of the "M-band" technique of Tremblay, Daniels, and Schaechter. The results of this work indicate that no significant release of DNA from the membrane could be detected after treatment with 0.25% PEA, a concentration previously shown to prevent reinitiation of DNA replication. However, concentrations of 0.5% PEA and greater, which stop DNA replication immediately, appear to release 25 to 80% of the DNA from the membrane.