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J Bacteriol. 1972 April; 110(1): 219-228
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Metabolism of Pyrimidines and Pyrimidine Nucleosides by Salmonella typhimurium

^a Department of Bacteriology, University of California, Davis, California 95616

ABSTRACT

The pathways by which uracil, cytosine, uridine, cytidine, deoxyuridine, and deoxycytidine are metabolized by Salmonella typhimurium are established. The various 5-fluoropyrimidine analogues are shown to exert their toxic effects only after having been converted to the nucleotide level, and these conversions are shown to be catalyzed by the same enzymes which similarly convert the natural substrates. Methods for isolating mutant strains blocked in various steps of metabolism of pyrimidine bases and nucleosides are described.

¹ Permanent address: Enzyme Division, University Institute of Biological Chemistry B, Copenhagen K, Denmark.

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