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J Bacteriol. 1972 April; 110(1): 439-441
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Effects of Acridine Orange on the Growth of Escherichia coli

¹ Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

ABSTRACT

Exposure of Escherichia coli to critical acridine orange (AO) concentrations did not result in loss of viability. However, the deoxyribonucleic acid (DNA) of cells exposed to such agents was rapidly degraded and repolymerized. On the other hand, a bacterium deficient in DNA repair (pol A₁^–, lacking DNA polymerase) was sensitive to the action of AO. The DNA of such cells was also degraded but it was not repaired.