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J Bacteriol. 1972 September; 111(3): 745-749
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

3',5'-Cyclic Adenosine Monophosphate-Requiring Mutants of Escherichia coli¹

^a Department of Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110

ABSTRACT

Mutants that require exogenous 3',5'-cyclic adenosine monophosphate (cAMP) for exponential growth were isolated from strains deficient in adenyl cyclase. Studies of one strain showed that cAMP is not incorporated into macromolecules; instead, it seems to have a regulatory function, i.e., in media lacking cAMP, cells form ribonucleic acid (RNA) and protein at linear rather than exponential rates. The exact lesion is not known; ribosomes, messenger RNA, and the ß and ß' subunits of RNA polymerase continue to be made in absence of added cAMP.

¹ A preliminary report on cAMP-requiring mutants was included in the proceedings of the Symposium on Effects of Drugs on Cellular Control Mechanisms, London, 1971.