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J Bacteriol. 1972 September; 111(3): 778-783
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Methionine Adenosyltransferase and Ethionine Resistance in Saccharomyces cerevisiae

¹ Department of Bacteriology and Public Health, Washington State University, Pullman, Washington 99163

ABSTRACT

The methionine adenosyltransferase is repressed in Saccharomyces cerevisiae during growth in the presence of excess methionine. The relationship of this repression to the level of intracellular S-adenosylmethionine is discussed. In conjunction with these studies, an ethionine-resistant mutant has been investigated which has a low level of methionine adenosyltransferase under all conditions tested. The mechanism of ethionine resistance in the latter strain apparently depends on its inability to form large quantities of intracellular S-adenosylethionine. With respect to the methionine adenosyltransferase, there is no apparent interaction between ethionine-resistant and ethionine-sensitive alleles when both are present in the heterozygous diploid.