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Klebsiella aerogenes Strain Carrying Drug-Resistance Determinants and a lac Plasmid

^a Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

ABSTRACT

In addition to carrying determinants conferring resistance to at least two antibiotics, chloramphenicol and streptomycin, a Klebsiella aerogenes strain contains a plasmid responsible for increased ß-galactosidase activity. The plasmid can be transferred to Escherichia coli and Salmonella typhimurium strains. K. aerogenes segregants without the plasmid grow on lactose one-half as fast as the parent strain and contain only one-tenth to one-fifth as much ß-galactosidase.

¹ Present address: Department of Microbiology, The Pennsylvania State University, University Park, Pa. 16802.