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J Bacteriol. 1972 December; 112(3): 1408-1415
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Relation Between Protein Synthesis and Phospholipid Synthesis and Turnover in Escherichia coli

Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77025

ABSTRACT

Turnover of phospholipids occurred continuously in a fatty acid auxotroph of Escherichia coli, but in the wild-type parent strain significant turnover occurred only under conditions where protein synthesis was inhibited but lipid synthesis continued. Both strains gave a stringent response of ribonucleic acid accumulation to amino acid starvation, but only in the wild type was lipid synthesis also inhibited. A revertant strain of the auxotroph resembled the wild type in this respect. The phospholipid that accumulates in the culture medium as a result of the lipid turnover appears to be part of a loosely bound low-density complex arising from the cell envelope.

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