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Host Range and Properties of the Pseudomonas aeruginosa R Factor R1822

¹ Department of Microbiology, The University of Michigan Medical School, Ann Arbor, Michigan 48104

ABSTRACT

R1822, a plasmid specifying multiple drug resistances, has been transferred to a variety of species representative of related and unrelated genera. The host range of the plasmid includes Enterobacteriaceae, soil saprophytes, Neisseria perflava, and photosynthetic bacteria. With the acquisition of drug resistance(s), these strains became sensitive to a small, ribonuclease-sensitive bacteriophage, designated PRR1, isolated by enrichment from sewage.

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