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Evidence for an Extrakaryotic Mutation Affecting the Maintenance of the rho Factor in Yeast

¹ Institut für Genetik der Universität München, 8 Munich 19, Germany

ABSTRACT

A newly isolated, temperature-sensitive mutant of a haploid strain of Saccharomyces cerevisiae is described. Its shift to nonpermissive temperature (35 C) resulted in an irreversible change to rho^–, causing, within four to six generations, more than 90% of the cells to form petite colonies. Genetic analysis revealed extrakaryotic inheritance of this temperature-sensitive mutation. Data presented indicate mutation of a gene in the mitochondrial deoxyribonucleic acid affecting the maintenance of the rho factor.