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Effects of Mutational Loss of Specific Intracellular Proteases on the Sporulation of Bacillus subtilis

^a Department of Biology, Yale University, New Haven, Connecticut 06520
Department of Chemistry, New Mexico State University, Las Cruces, New Mexico 88001

ABSTRACT

Two protease-deficient mutants of Bacillus subtilis 168 (Trp^–) were isolated and compared with the parental strain with respect to production of intracellular proteases and sporulation. A mutant lacking the metal-requiring "neutral" protease intracellularly sporulated as well as the parental strain. A second mutant, deficient in an as yet uncharacterized intracellular protease, failed to sporulate normally. It is proposed that this new protease is also involved in intracellular protein turnover.

¹ Present address: Department of Chemistry, New Mexico State University, Las Cruces, N. M. 88001.

² Present address: Departments of Biochemistry and Microbiology, University of Georgia, Athens, Ga. 30601.