This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Buettner, M. J. Articles by Rickenberg, H. V. Search for Related Content PubMed PubMed Citation Articles by Buettner, M. J. Articles by Rickenberg, H. V.

Cyclic Adenosine 3',5'-Monophosphate in Escherichia coli

^a Division of Research, National Jewish Hospital and Research Center, and Department of Biophysics and Genetics, University of Colorado School of Medicine, Denver, Colorado 80206

ABSTRACT

The concentration of cyclic adenosine 3',5'-monophosphate (c-AMP) in Escherichia coli growing on different sources of carbon was studied. Cultures utilizing a source of carbon that supported growth relatively poorly had consistently higher concentrations of c-AMP than did cultures utilizing sugars that supported rapid growth. This relationship was also observed in strains defective in c-AMP phosphodiesterase and simultaneously resistant to catabolite repression; in such strains the c-AMP concentration was slightly higher for several sources of carbon tested. Cultures continued to synthesize c-AMP and secreted it into the medium, under conditions that brought about an inhibition of the intracellular accumulation of the cyclic nucleotide. Transient repression of the synthesis of ß-galactosidase was not associated with an abrupt decrease in the cellular concentration of c-AMP.

¹ Present address: Department of Cell Biology, University of Kentucky Medical Center, Lexington, Kentucky.

This article has been cited by other articles:

• Lange, R, Hengge-Aronis, R (1994). The cellular concentration of the sigma S subunit of RNA polymerase in Escherichia coli is controlled at the levels of transcription, translation, and protein stability.. Genes Dev. 8: 1600-1612 [Abstract]