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J Bacteriol. 1973 June; 114(3): 928-933
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

S-Adenosyl Methionine-Mediated Repression of Methionine Biosynthetic Enzymes in Saccharomyces cerevisiae

H. Cherest, Y. Surdin-Kerjan, J. Antoniewski and H. De Robichon-Szulmajster

1 Laboratoire d'Enzymologie, Centre National de la Recherche Scientifique, 91190 Gif-sur-Yvette, France

ABSTRACT

S-adenosylmethionine (SAM) has been shown to provoke repression of some methionine-specific enzymes in wild-type cells, namely, adenosine triphosphate sulfurylase, sulfite reductase, and homocysteine synthetase. Repressive effects observed in SAM-supplemented cultures should be due to SAM per se, since the intracellular pool of SAM increases while the intracellular pool of methionine remains low and constant. Derepression brought about by methionine limitation is accompanied by a severe decrease in SAM as well as methionine pool sizes, although methionine adenosyl transferase is slightly derepressed. Different hypotheses have been considered to account for the previously reported implication of methionyl transfer ribonucleic acid and the presently reported SAM effects in this regulatory process.

J Bacteriol. 1973 June; 114(3): 928-933
Copyright © 1973 American Society for Microbiology. All Rights Reserved.



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