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J Bacteriol. 1973 July; 115(1): 162-167
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Bacterial Metabolism of 3-Hydroxy-3-Methylglutaric Acid

^a Biochemistry Division, Department of Chemistry, Aligarh Muslim University, Aligarh, India

ABSTRACT

An organism belonging to Pseudomonadaceae and capable of utilizing 3-hydroxy-3-methylglutarate as sole carbon source has been isolated from soil. Whole-cell preparations catalyze the oxidation of acetoacetate, acetate, glyoxylate, and citric acid cycle intermediates. Cell-free extracts of 3-hydroxy-3-methylglutarate-grown cells show an adenosine triphosphate, coenzyme A (CoA), and Mg²⁺-dependent conversion of 3-hydroxy-3-methylglutarate to 3-hydroxy-3-methylglutaryl-CoA. Succinyl-CoA-generating system has no effect on the activation and catabolism of 3-hydroxy-3-methylglutarate.

¹ Present Address: Institute of Ophthalmology, J. N. Medical College, Aligarh Muslim University, Aligarh, India.