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Effect of Biogenic Amines and Cannabinoids on Bacterial Chemotaxis

¹ Department of Plant Pathology and Microbiology, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel, and Laboratory of Applied Biology, Division of Engineering and Applied Physics, Harvard University, Cambridge, Massachusetts 02138

ABSTRACT

The chemotactic response of Pseudomonas fluorescens was significantly enhanced by the stimulants DL-amphetamine and epinephrine. Acetylcholine, a physiological antagonist of epinephrine, and the cannabinoid tetrahydrocannabinol inhibited bacterial chemotaxis. It may be possible to use bacterial chemotaxis as a bioassay in biochemical studies of drug action.

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