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Accumulation of Methylglyoxal in a Mutant of Escherichia coli Constitutive for Gluconate Catabolism

^a Departamento de Biología Celular, Facultad de Ciencias, Ap. 10098, Universidad Central de Venezuela, Caracas, Venezuela

ABSTRACT

A culture of a mutant of Escherichia coli, derepressed for gluconate catabolism, is killed by the addition of gluconate to the culture. The product responsible for this bactericidal effect was identified as methylglyoxal. Two types of mutants resistant to gluconate were isolated. One of them showed increased activity of glyoxalase I.

¹ Present address: Centro de Investigaciones Microbiológicas, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina.

² Present address: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Mass.