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Non-Continuous Translation of Coat Protein and Ribonucleic Acid Polymerase Cistrons in MS2 Bacteriophage Ribonucleic Acid

^a Department of Biochemistry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261

ABSTRACT

In an MS2 phage ribonucleic acid (RNA)-directed in vitro protein-synthesizing system, the coat protein cistron and the adjacent RNA polymerase cistron are translated non-continuously. The ribosomes which have completed the synthesis of coat protein dissociate from the MS2 RNA and do not read through the intercistronic gap. Translation of the adjacent RNA polymerase cistron requires ribosomes other than those translating the coat protein cistron.

¹ Present address: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, N.Y. 10461.