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Mutants of Group D₁Salmonella Carrying the Somatic Antigen of Group A Organisms: Isolation and Serological Characterization

Cancer Research Institute, Sapporo Medical College, Sapporo 060, Japan

ABSTRACT

O antigen mutants were obtained from Salmonella durban, a group D₁ organism, by treatment with N-methyl-N'-nitro-N-nitrosoguanidine. Serological studies demonstrated that the mutants lost the O-9 antigen factor of the parent organism but acquired the O-2 factor specific to group A Salmonella. Lipopolysaccharides of the mutant strains contained paratose which determines the specificity of O-2 factor. Tyvelose, present in the wild-type lipopolysaccharide, was not found in the mutants. H antigens and other biological characteristics of the mutant strains were the same as those of the wild-type organism. The present finding implies that group A Salmonella species might be derived from group D₁ organisms.