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J Bacteriol. 1974 February; 117(2): 432-438
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Cyclic Adenosine 3',5'-Monophosphate and Morphogenesis in Mucor racemosus

Alf D. Larsen and Paul S. Sypherd

Department of Medical Microbiology, College of Medicine, University of California, Irvine, Irvine, California 92664

ABSTRACT

Yeastlike cells of Mucor racemosus grown under 100% CO2 underwent morphogenesis to hyphae after exposure to air. The addition of dibutyryl cyclic adenosine monophosphate (dbcAMP) to yeastlike cultures inhibited this morphogenesis in media containing 2% glucose. The maintenance of uniformly spherical, budding cells required 1 mM dbcAMP in a defined medium containing Casamino Acids, and 3 mM dbcAMP in a medium containing yeast extract and peptone. At these concentrations, dbcAMP also induced yeastlike development in young aerobic hyphae grown in media containing 2% glucose. Removal of dbcAMP resulted in hyphal development. The endogenous cyclic AMP (cAMP) content of yeastlike cultures was measured after a shift from CO2 to air. A fourfold decrease in intracellular cAMP preceded the appearance of hyphal germ tubes. These results indicate that cAMP plays a role in the control of morphogenesis in Mucor racemosus.

J Bacteriol. 1974 February; 117(2): 432-438
Copyright © 1974 American Society for Microbiology. All Rights Reserved.



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