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J Bacteriol. 1974 July; 119(1): 33-35
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Mutagenesis by Mutator Gene mutH1 in Continuous Cultures of Escherichia coli

Earle R. Nestmann and Ruth F. Hill1

a Department of Biology, York University, Downsview, Ontario, M3J 1P3 Canada

ABSTRACT

Mutability as a function of growth rate was examined in bacterial strains containing mutator gene mutH1. The rate of mutation to bacteriophage T5 resistance was found to be proportional to rate of growth in glucose-limited chemostat cultures. This finding supports the hypothesis that the mutator mutH1 gene product increases the error frequency during deoxyribonucleic acid replication.

FOOTNOTES

1 Deceased.

J Bacteriol. 1974 July; 119(1): 33-35
Copyright © 1974 American Society for Microbiology. All Rights Reserved.





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Copyright © 1974 by the American Society for Microbiology. All rights reserved.