This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lawther, R. P. Articles by Cooper, T. G. Search for Related Content PubMed PubMed Citation Articles by Lawther, R. P. Articles by Cooper, T. G.

Clustering of the Genes for Allantoin Degradation in Saccharomyces cerevisiae

¹ Department of Biochemistry, Faculty of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

ABSTRACT

We have shown that allantoin degradation in Saccharomyces cerevisiae proceeds exclusively through the intermediate formation of allantoic acid, urea, and allophanic acid. The number of reactions between allantoic acid and urea, however, remains obscure owing to our inability to isolate a mutant defective in ureidoglycolate hydrolase. Structural genes for the enzymes, allantoinase (dal1) and allantoicase (dal2) are located on chromosome IX promixal to the centromere in the order dal1-dal2-lysl.