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Isolation and Partial Characterization of a Temperature-Sensitive Escherichia coli Mutant with Altered Glutaminyl-Transfer Ribonucleic Acid Synthetase

^a Department of Molecular Biophysics and Biochemistry and Department of Microbiology, Yale University, New Haven, Connecticut 06520

ABSTRACT

A temperature-sensitive mutant of Escherichia coli has been found in which the conditional growth is a result of a thermosensitive glutaminyl-transfer ribonucleic acid synthetase. The corresponding genetic locus glnS is cotransduced with lip. In a strain containing the mutationally altered glutaminyl-transfer ribonucleic acid synthetase, no derepression of the enzyme itself nor of glutamine synthetase was observed.

¹ Present address: Institute of Biophysics, Czechoslovakia Academy of Science, Brno.

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• Perona, J., Swanson, R., Rould, M., Steitz, T., Soll, D (1989). Structural basis for misaminoacylation by mutant E. coli glutaminyl-tRNA synthetase enzymes. Science 246: 1152-1154 [Abstract]