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Effect of Cyclic Guanosine 3',5'-Monophosphate on the Synthesis of Enzymes Sensitive to Catabolite Repression in Intact Cells of Escherichia coli

¹ Department of Pathology, Methodist Hospital, and SUNY Downstate Medical Center, Brooklyn, New York 11215

ABSTRACT

Cyclic guanosine 3',5'-monophosphate inhibits the synthesis of ß-galactosidase and tryptophanase in cultures of Escherichia coli growing in minimal media with glucose or glycerol as the carbon source. Cyclic guanosine 3',5'-monophosphate acts at the transcriptional level in the lac operon, it exerts its action at the promoter site of the operon, and requires the presence of functional cyclic adenosine 3',5'-monophosphate receptor protein.