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J Bacteriol. 1974 December; 120(3): 1209-1212
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Apparent Mutagenic Effect of Induction of Lambda Prophage Inserted Between lysA and thyA

^a Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48104

ABSTRACT

Induction of a heat-inducible abnormal lambda prophage inserted between lysA and thyA in Escherichia coli resulted in a number of auxotrophic mutants in the surviving cured-cell populations. These mutants could not be accounted for by deletions arising on formation of lambda hybrid particles carrying regions adjacent to the insertion site. The properties of these mutants, which were almost all spontaneously revertable, have been described and mapped by F' episome complementation. Tentatively, it was suggested that induction of the lambda lysogen leads to a mutagenic state.

¹ Present address: Fermentation Research and Development Unit, Upjohn Company, Kalamazoo, Mich 49001.