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J Bacteriol. 1975 April; 122(1): 199-205

Tryptophan photoproduct(s): sensitized induction of strand breaks (or alkali-labile bonds) in bacterial deoxyribonucleic acid during near-ultraviolet irradiation.

ABSTRACT

Long-wavelength ultraviolet light (300 to 400 nm) converts L-tryptophan to a photoproduct that is toxic for bacterial cells in dark conditions. We now report that similar photoproducts of l-tryptophan sensitize bacterial deoxyribonucleic acid to 365-nm radiation, increasing the yield of deoxyribonucleic acid strand breaks (or alkali-labile bonds) by approximately 11.5-fold. Evidence is also presented which indicates that thse sensitized deoxyribonucleic acid lesions contribute to lethality for Escherichia coli irradiated with 365-nm ultraviolet light in suspensions of tryptophan photoproducts.

This article has been cited by other articles:

• McCormick, J., Fischer, JR, Pachlatko, J., Eisenstark, A (1976). Characterization of a cell-lethal product from the photooxidation of tryptophan: hydrogen peroxide. Science 191: 468-469 [Abstract]