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J Bacteriol. 1975 May; 122(2): 532-537

Characterization of an inhibitor of ribonucleic acid polymerase from the mycelial phase of Histoplasma capsulatum.

G Boguslawski, G S Kobayashi, D Schlessinger and G Medoff

ABSTRACT

An inhibitor of ribonucleic acid polymerases has been obtained from the mycelial phase of Histoplasma capsulatum and partially characterized. The inhibitor, called histin, was purified 200-fold by heat treatment at 100 C and electrophoresis on polyacrylamide gels. Histin moved in electrophoresis as if negatively charged; it was insensitive to treatment with ribonuclease of deoxyribonuclease but was completely digested by Pronase. Sucrose gradient centrifugation suggests a molecular weight of 24,000. The possibility of a regulatory role for histin in the life cycle of H. capsulatum is discussed.

J Bacteriol. 1975 May; 122(2): 532-537






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