This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Crawford, R L Search for Related Content PubMed PubMed Citation Articles by Crawford, R L

 Previous Article  |  Next Article 

J Bacteriol. 1976 July; 127(1): 204-210

Pathways of 4-hydroxybenzoate degradation among species of Bacillus.

ABSTRACT

The pathways used by three bacterial strains of the genus Bacillus to degrade 4-hydroxybenzoate are delineated. When B. brevis strain PHB-2 is grown on 4-hydroxybenzoate, enzymes of the protocatechuate branch of the beta-ketoadipate pathway are induced. In contrast, B. circulans strain 3 contains high levels of the enzymes of the protocatechuate 2,3-dioxygenase pathway after growth on 4-hydroxybenzoate. B. laterosporus strain PHB-7a degrades 4-hydroxybenzoate by a novel reaction sequence. After growth on 4-hydroxybenzoate, strain PHB-7a contains high levels of gentisate oxygenase (EC 1.13.11.4) and maleylpyruvate hydrolase. Whole cells of strain PHB-7a (grown on 4-hydroxylbenzoate) accumulate 2,5-dihydroxybenzoate (gentisate) from 4-hydroxybenzoate when incubated in the presence of 1mM alpha,alpha'-dipyridyl. Thus, strain PHB-7a appears to convert 4-hydroxybenzoate to gentisate, which is further degraded by the glutathione-independent gentisic acid pathway. These pathway delineations provide evidence that Bacillus species are derived from a diverse evolutionary background.

This article has been cited by other articles:

• Peng, X., Misawa, N., Harayama, S. (2003). Isolation and Characterization of Thermophilic Bacilli Degrading Cinnamic, 4-Coumaric, and Ferulic Acids. Appl. Environ. Microbiol. 69: 1417-1427 [Abstract] [Full Text]  
• Fairley, D. J., Boyd, D. R., Sharma, N. D., Allen, C. C. R., Morgan, P., Larkin, M. J. (2002). Aerobic Metabolism of 4-Hydroxybenzoic Acid in Archaea via an Unusual Pathway Involving an Intramolecular Migration (NIH Shift). Appl. Environ. Microbiol. 68: 6246-6255 [Abstract] [Full Text]  
• Gescher, J., Zaar, A., Mohamed, M., Schagger, H., Fuchs, G. (2002). Genes Coding for a New Pathway of Aerobic Benzoate Metabolism in Azoarcus evansii. J. Bacteriol. 184: 6301-6315 [Abstract] [Full Text]  
• Zaar, A., Eisenreich, W., Bacher, A., Fuchs, G. (2001). A Novel Pathway of Aerobic Benzoate Catabolism in the Bacteria Azoarcus evansii and Bacillus stearothermophilus. J. Biol. Chem. 276: 24997-25004 [Abstract] [Full Text]