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J Bacteriol. 1977 October; 132(1): 100-105

Regulatory mutations in the Klebsiella aerogenes structural gene for glutamine synthetase.

R A Bender and B Magasanik

ABSTRACT

Glutamine synthetase could be repressed several hundredfold rather than 6- to 10-fold as previously reported. Ammonia was not the primary repression signal for glutamine synthetase. Repression appeared to be mediated by a high level of glutamine and probably by a high ratio of glutamine to alpha-ketoglutarate. Mutations in glnA (the structural gene for glutamine synthetase) were seen to fall into three phenotypic groups: glutamine auxotrophs that produced no detectable glnA product; glutamine auxotrophs that produced a glnA product lacking enzymatic activity (and hence repressibility by ammonia) but were repressible under appropriate conditions; and glutamine synthetase regulatory mutants, whose glnA product was enzymatically active and not repressible under any conditions.

J Bacteriol. 1977 October; 132(1): 100-105




This article has been cited by other articles:

  • Tamura, G. S., Nittayajarn, A., Schoentag, D. L. (2002). A Glutamine Transport Gene, glnQ, Is Required for Fibronectin Adherence and Virulence of Group B Streptococci. Infect. Immun. 70: 2877-2885 [Abstract] [Full Text]  
  • Goss, T. J., Perez-Matos, A., Bender, R. A. (2001). Roles of Glutamate Synthase, gltBD, and gltF in Nitrogen Metabolism of Escherichia coli and Klebsiella aerogenes. J. Bacteriol. 183: 6607-6619 [Abstract] [Full Text]  


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