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J Bacteriol. 1980 May; 142(2): 455-461

Resistance to thiostrepton, siomycin, and sporangiomycin in actinomycetes that produce them.

J Thompson and E Cundliffe

ABSTRACT

The antibiotics thiostrepton, siomycin, and sporangiomycin are closely related both in structure and in mode of action. Actinomycetes which produce this group of compounds possess ribonucleic acid-pentose methylases, which act upon 23S ribosomal ribonucleic acid and render ribosomes resistant to the action of these antibiotics. This is achieved via the formation of a single residue of 2'-O-methyladenosine per ribosome.


J Bacteriol. 1980 May; 142(2): 455-461







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